Biocatalytic Method for the Synthesis of Enantiomerically Pure β-Methyl-phenylethylamines

A new method for the synthesis of important building blocks − enantiomerically pure β-methyl-phenylethylamines − has been developed. Kinetic dynamic enzymatic resolution methodology was applied at key stages of the synthesis. A double biocatalytic purification approach was used to achieve high optical purity of the obtained products. The resulting amines are promising building blocks for the development and production of new pharmaceuticals and biologically active compounds.