CTE / Proceedings 2025 / Airflow and Mass Transfer Modeling as a Tool for Analyzing Drug Aerosolization and Delivery

Airflow and Mass Transfer Modeling as a Tool for Analyzing Drug Aerosolization and Delivery

DOI: https://doi.org/10.23939/cte2025.01.030
Computer Simulation in the Chemical Technology and Engineering
pp.
30-33
Abstract

Chemical engineering methodology can be effectively used to solve problems of physiology, pharmacology, and medicine. Here, we present selected examples of such applications, focusing on numerical and experimental investigations of aerosol generation in inhalers of different types (e.g., dry powder inhalers, nebulizers) and particle dynamics during inhalation and drug deposition in different parts of the respiratory system. It is demonstrated how such an analysis helps to design more effective inhalers and pharmaceutical formulations for targeted and personalized drug delivery. Future directions of aerosol therapy with a potential input of chemical engineering are also proposed.

Keywords (in English)
aerosols
CFD
medical applications
inhalers
mass transfer in the lungs
Author (co-authors)
First name Last name Institutional affiliation E-mail Phone number ORCID ID Academic status, position Institution address Author contribution(s) Institutional affiliation
Tomasz
Sosnowski
tomasz.sosnowski@pw.edu.pl
0000-0002-6775-3766
professor, Vice-Dean for Science and Development
Waryńskiego 1 00-645 Warsaw Poland
Conceptualization
Formal Analysis
Funding Acquisition
Methodology
Project Administration
Writing – Original Draft Preparation
Writing – Review & Editing
Warsaw University of Technology Faculty of Chemical and Process Engineering
Agata
Dorosz
agata.dorosz@pw.edu.pl
0000-0002-8487-0390
assistant professor
Waryńskiego 1 00-645 Warsaw Poland
Investigation
Writing – Review & Editing
Warsaw University of Technology Faculty of Chemical and Process Engineering
Arkadiusz
Moskal
arkadiusz.moskal@pw.edu.pl
0000-0002-1114-526X
professor
Waryńskiego 1 00-645 Warsaw Poland
Conceptualization
Formal Analysis
Writing – Review & Editing
Warsaw University of Technology Faculty of Chemical and Process Engineering
Maciej
Małecki
maciej.malecki@wum.edu.pl
0000-0002-7078-4918
professor, Head of Department of Applied Pharmacy
Banacha 1 02-097 Warsaw Poland
Conceptualization
Funding Acquisition
Writing – Review & Editing
Medical University of Warsaw Faculty of Pharmacy
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