Recent advances in organ-on-chip technology provide innovative platforms for studying ophthalmic diseases. These microphysiological systems mimic the complex in vivo microenvironment, enabling more precise disease modeling and drug testing. This paper reviews the latest developments in corneal and retinal organ-on-chip models, highlighting their potential to revolutionize ophthalmic research and personalized medicine.
[1] Bourne, R. R. A., Flaxman, S. R., Braithwaite, T., Cicinelli, M. V., Das, A., Jonas, J. B., Keeffe, J., Kempen, J. H., Leasher, J., Limburg, H., Naidoo, K., Pesudovs, K., Resnikoff, S., Silvester, A., Stevens, G. A., Tahhan, N., Wong, T. Y., & Taylor, H. R.; Vision Loss Expert Group. (2017). Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis. The Lancet. Global Health, 5(9), e888–e897. DOI: 10.1016/S2214-109X(17)30293-0
[2] Pascolini, D., & Mariotti, S. P. (2012). Global estimates of visual impairment: 2010. The British Journal of Ophthalmology, 96(5), 614–618. DOI: 10.1136/bjophthalmol-2011-300539
[3] Zhang, J., Tuo, J., Wang, Z., Zhu, A., Machalińska, A., & Long, Q. (2015). Pathogenesis of Common Ocular Diseases. Journal of Ophthalmology, 2015, 734527. DOI: 10.1155/2015/734527
[4] Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (2021). Organs-on-chips: into the next decade. Nature Reviews Drug Discovery, 20(5), 345–361. DOI: 10.1038/s41573-020-0079-3
[5] Mannis, M. J., & Holland, E. J. (2021). Cornea. Elsevier Health Sciences.
[6] Forrester, J. V., Dick, A. D., McMenamin, P., Roberts, F., & Pearlman, E. (2021). The Eye. Elsevier.
[7] Ptito, M., Bleau, M., & Bouskila, J. (2021). The Retina: A Window into the Brain. Cells, 10(12), 3269. DOI: 10.3390/cells10123269
[8] Puleo, C. M., Ambrose, W. M., Takezawa, T., Elisseeff, J., & Wang, T. H. (2009). Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture. Lab on a Chip, 9(22), 3221–3227. DOI: 10.1039/B908332D
[9] Bennet, D., Estlack, Z., Reid, T., & Kim, J. (2018). A microengineered human corneal epithelium-on-a-chip for eye drops mass transport evaluation. Lab on a Chip, 18(11), 1539–1551. DOI: 10.1039/C8LC00158H
[10] Seo, J., Byun, W. Y., Alisafaei, F., Georgescu, A., Yi, Y. S., Massaro-Giordano, M., & Huh, D. (2019). Multiscale reverse engineering of the human ocular surface. Nature Medicine, 25(8), 1310–1318. DOI: 10.1038/s41591-019-0531-2
[11] Su, P. J., Liu, Z., Zhang, K., et al. (2015). Retinal synaptic regeneration via microfluidic guiding channels. Scientific Reports, 5, 13591. DOI: 10.1038/srep13591
[12] Mishra, S., Thakur, A., Redenti, S., & Vazquez, M. (2015). A model microfluidics-based system for the human and mouse retina. Biomedical Microdevices, 17(6), 107. DOI: 10.1007/s10544-015-0002-6
[13] Dodson, K. H., Echevarria, F. D., Li, D., Sappington, R. M., & Edd, J. F. (2015). Retina-on-a-chip: a microfluidic platform for point access signaling studies. Biomedical Microdevices, 17(6), 114. DOI: 10.1007/s10544-015-0019-x
[14] Oosten, E. M., & ávan der Meer, A. D. (2025). Retina-on-Chip: Engineering Functional in vitro Models of the Human Retina using Organ-on-Chip Technology. Lab on a Chip. DOI: 10.1039/D4LC00823E